Integrate granulation drying milling and blending into one continuous process

The Gansons Integrated Granulation Line is a complete wet granulation solution that connects all critical processing steps into a single coordinated system. The line typically includes a high shear mixer granulator, inline wet mill, fluid bed dryer, dry milling system, and IBC blender, enabling controlled material flow from raw powder to final blend.

Each process step is engineered to work in balance with the others, creating a continuous manufacturing sequence with predictable throughput and minimal manual intervention. Closed material transfer between units reduces handling, limits operator exposure, and improves process reliability.

The system is controlled through a centralized automation platform that manages process parameters across all units. This ensures consistent batch reproducibility, supports recipe-driven operation, and enables compliance with pharmaceutical data integrity requirements such as 21 CFR Part 11.

The integrated design reduces downtime through synchronized equipment operation, fast changeovers, and clean-in-place functionality. The line can be configured for different batch sizes and scaled from development to full production, maintaining consistent process performance across capacities.

The equipment is designed for pharmaceutical environments, with high-containment options, ATEX-compliant configurations, and construction materials suitable for regulated production.

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Reduce drying time and improve uniformity with controlled fluidization

The Gansons Fluidised Bed Dryer is designed to dry powders and granules by suspending particles in a controlled stream of heated air, ensuring uniform contact between air and material. This fluidization enables consistent moisture removal across the entire batch while maintaining product integrity.

The system features a proprietary Cyklon air distribution design that generates a controlled swirl-flow pattern inside the process chamber. This eliminates dead zones and prevents material stagnation, significantly improving drying efficiency while reducing particle attrition and product loss.

The airflow system allows precise control over drying parameters, supported by push-pull fan configuration for stable and reproducible process conditions. This results in shorter drying times and consistent batch outcomes, even for sensitive or high-value materials.

The equipment is designed for pharmaceutical production environments, with cGMP-compliant construction, wash-in-place systems, and options for high-containment processing. Automation systems support recipe control, data integrity, and integration into regulated production workflows.

The system is scalable from development to production, with capacities ranging from approximately 10 L to 1,500 L.

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Achieve rapid and uniform wet granulation with controlled mixing and shear

The Gansons High Shear Mixer Granulator is designed for fast and controlled wet granulation of pharmaceutical powders, combining high-intensity mixing with precise binder distribution and granule formation. The system enables solid-solid and solid-liquid processing within a single vessel, producing dense and uniform granules for tablet formulation.

The process is driven by a proprietary impeller and chopper configuration that creates strong vortex movement and efficient powder recirculation. This ensures homogeneous mixing across varying bulk densities while promoting rapid granule growth and consistent particle size distribution.

The chopper supports both binder distribution and deagglomeration, preventing oversized agglomerates and improving granule uniformity. The optimized process bowl geometry eliminates dead zones and enhances material flow into the shear zone, ensuring repeatable processing results.

Integrated automation monitors parameters such as torque, power, and time to enable accurate end-point detection and reproducible batch performance. The system supports recipe-driven operation and complies with regulatory requirements for data integrity and process control.

The equipment is designed for safe pharmaceutical production with features such as wash-in-place cleaning, sealed shaft systems to prevent contamination, and optional ATEX-compliant designs. Available in capacities ranging from laboratory to large-scale production, the system supports scalable process development and manufacturing.

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Achieve uniform and reproducible tablet coating at scale

The Gansons GansCoater is a high-performance tablet coating system designed for pharmaceutical production environments requiring consistent coating quality and regulatory compliance. The system supports a wide range of coating applications including film coating, enteric coating, multi-layer functional coating, and sugar coating.

The coating process is optimized through a combination of proprietary spray nozzles, controlled air handling, and engineered mixing dynamics inside the coating pan. The GHPN spray nozzles generate uniform droplet size with wide coverage, reducing spray losses and compressed air consumption while maintaining consistent coating distribution.

The coating drum is designed with a highly polished surface and optimized perforation geometry to improve drying efficiency and reduce tablet abrasion. Aeroflo baffles enhance tablet movement and airflow interaction, eliminating dead zones and improving mixing performance and coating uniformity.

The system supports fast changeovers through interchangeable coating pans and automated loading and unloading. Integrated process control with PLC or SCADA systems ensures reproducible operation, recipe management, and compliance with regulatory standards such as 21 CFR Part 11.

The GansCoater is available across a wide capacity range from laboratory to large-scale production, with batch sizes ranging from approximately 500 g up to 1,000 kg.

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Inspect ampoules and vials with highly reliable semi-automatic machines

Rota offers inspection of parenteral liquid drug through semi and fully automated inspection machines with state of the art camera systems.  The semi-automatic machines are cost-effective, reproducible and can be systematically validated.

The integrated cameras capture images of the objects to be inspected and send these magnified up to 10 times on the LCD screen. Because nothing checks more reliably than a human being, up to six objects are presented to the operator at simultaneously, who can then decide quickly whether the liquid is free of particles or not. The machines can reach a speed of up to 6.000 per hour for the ampoules.

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A processing machine for nested and pre-sterilized syringes

Rota has decades of experience as a supplier for the pharmaceutical industry. This processing machine for nested and per-sterilized syringes is a translation and integration of Rota’s experience for meeting the customer needs.

They main feature is the use of latest servo motor technology. Serial kinematics robotics (SCARA) and advanced control programming allow the precise execution of each individual processing step. It is provided with automated systems for de-bagging, lid and fleece inlay removal. The machine capacity covers a range of up to 22.000 syringes per hour.

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Tailor made labeling solutions for ampoules, vials and bottles

The labeling machines of Rota meet all requirements of the pharmaceutical industry in an optimal manner. You need properly attached and error-free labels to market your drugs. Rota machines are ideal for integration of any kind of control and printing features from various manufacturers, with top precision at high speeds.

Flexible solutions at in-feed and out-feed of the labeller allow its integration into packaging lines from other manufacturers, as well. Upright transport of all containers, whether of glass or plastic, guarantees a high precision application of labels. Rota labeling machines for ampoules, vials and bottles can label up to 24.000 containers per hour.

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Customisable Ampoule filling machine with the highest filling accuracy

Rota’s filling machines allow the filling from small scale batches to mass production with optimal performance range. Filling can be done for the ampoules and vials that are from 0.2 ml to 30 ml and can afford up to 24.000 per hour.

Ampoules are the perfect containers to store parenteral fluids and their filling demands rigidly controlled sterile conditions. Rota’s own rotary pumps guarantee high filling accuracy in continuous operation without re-adjustment. This Ampoule filling machine comes with an easy to handle approach when looking to clean and sterilise the filling system, whether manually or with automatic CIP/SIP systems.

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Compresses and Shapes Tablets for R&D

The FlexiTab XL from Syntegon is a versatile single punch tablet press that caters to the unique production challenges in pharmaceutical, nutraceutical, and confectionery industries. Designed for early-stage R&D and clinical trials, this machine excels in producing a wide range of tablets and oblong forms, including multi-layered dosages with up to three APIs. The FlexiTab XL offers precise control over layering and sequencing, thanks to its enhanced data acquisition (DAQ) software. Capable of rapid changeovers, it supports tight schedule demands in research and development environments. The machine’s compact design ensures seamless integration into existing labs, while its hygienic build meets cGMP standards, facilitating fast and easy cleaning. Fully manual or automated sequencing of tablet production accommodates varied operational needs, making it a highly adaptable tool for any tablet formulation requirement.

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