Integrate granulation drying milling and blending into one continuous process

The Gansons Integrated Granulation Line is a complete wet granulation solution that connects all critical processing steps into a single coordinated system. The line typically includes a high shear mixer granulator, inline wet mill, fluid bed dryer, dry milling system, and IBC blender, enabling controlled material flow from raw powder to final blend.

Each process step is engineered to work in balance with the others, creating a continuous manufacturing sequence with predictable throughput and minimal manual intervention. Closed material transfer between units reduces handling, limits operator exposure, and improves process reliability.

The system is controlled through a centralized automation platform that manages process parameters across all units. This ensures consistent batch reproducibility, supports recipe-driven operation, and enables compliance with pharmaceutical data integrity requirements such as 21 CFR Part 11.

The integrated design reduces downtime through synchronized equipment operation, fast changeovers, and clean-in-place functionality. The line can be configured for different batch sizes and scaled from development to full production, maintaining consistent process performance across capacities.

The equipment is designed for pharmaceutical environments, with high-containment options, ATEX-compliant configurations, and construction materials suitable for regulated production.

The post Zintegrowana linia granulacji do produkcji tabletek farmaceutycznych appeared first on Vekamaf.com Poland.

Reduce drying time and improve uniformity with controlled fluidization

The Gansons Fluidised Bed Dryer is designed to dry powders and granules by suspending particles in a controlled stream of heated air, ensuring uniform contact between air and material. This fluidization enables consistent moisture removal across the entire batch while maintaining product integrity.

The system features a proprietary Cyklon air distribution design that generates a controlled swirl-flow pattern inside the process chamber. This eliminates dead zones and prevents material stagnation, significantly improving drying efficiency while reducing particle attrition and product loss.

The airflow system allows precise control over drying parameters, supported by push-pull fan configuration for stable and reproducible process conditions. This results in shorter drying times and consistent batch outcomes, even for sensitive or high-value materials.

The equipment is designed for pharmaceutical production environments, with cGMP-compliant construction, wash-in-place systems, and options for high-containment processing. Automation systems support recipe control, data integrity, and integration into regulated production workflows.

The system is scalable from development to production, with capacities ranging from approximately 10 L to 1,500 L.

The post Suszarka fluidyzacyjna do suszenia proszku farmaceutycznego appeared first on Vekamaf.com Poland.

Achieve rapid and uniform wet granulation with controlled mixing and shear

The Gansons High Shear Mixer Granulator is designed for fast and controlled wet granulation of pharmaceutical powders, combining high-intensity mixing with precise binder distribution and granule formation. The system enables solid-solid and solid-liquid processing within a single vessel, producing dense and uniform granules for tablet formulation.

The process is driven by a proprietary impeller and chopper configuration that creates strong vortex movement and efficient powder recirculation. This ensures homogeneous mixing across varying bulk densities while promoting rapid granule growth and consistent particle size distribution.

The chopper supports both binder distribution and deagglomeration, preventing oversized agglomerates and improving granule uniformity. The optimized process bowl geometry eliminates dead zones and enhances material flow into the shear zone, ensuring repeatable processing results.

Integrated automation monitors parameters such as torque, power, and time to enable accurate end-point detection and reproducible batch performance. The system supports recipe-driven operation and complies with regulatory requirements for data integrity and process control.

The equipment is designed for safe pharmaceutical production with features such as wash-in-place cleaning, sealed shaft systems to prevent contamination, and optional ATEX-compliant designs. Available in capacities ranging from laboratory to large-scale production, the system supports scalable process development and manufacturing.

The post Granulator z mieszadłem szybkoobrotowym do granulacji na mokro proszków farmaceutycznych appeared first on Vekamaf.com Poland.

Achieve uniform and reproducible tablet coating at scale

The Gansons GansCoater is a high-performance tablet coating system designed for pharmaceutical production environments requiring consistent coating quality and regulatory compliance. The system supports a wide range of coating applications including film coating, enteric coating, multi-layer functional coating, and sugar coating.

The coating process is optimized through a combination of proprietary spray nozzles, controlled air handling, and engineered mixing dynamics inside the coating pan. The GHPN spray nozzles generate uniform droplet size with wide coverage, reducing spray losses and compressed air consumption while maintaining consistent coating distribution.

The coating drum is designed with a highly polished surface and optimized perforation geometry to improve drying efficiency and reduce tablet abrasion. Aeroflo baffles enhance tablet movement and airflow interaction, eliminating dead zones and improving mixing performance and coating uniformity.

The system supports fast changeovers through interchangeable coating pans and automated loading and unloading. Integrated process control with PLC or SCADA systems ensures reproducible operation, recipe management, and compliance with regulatory standards such as 21 CFR Part 11.

The GansCoater is available across a wide capacity range from laboratory to large-scale production, with batch sizes ranging from approximately 500 g up to 1,000 kg.

The post Maszyna do powlekania tabletek dla jednolitych powłok farmaceutycznych i funkcjonalnych appeared first on Vekamaf.com Poland.

Compresses and Shapes Tablets for R&D

The FlexiTab XL from Syntegon is a versatile single punch tablet press that caters to the unique production challenges in pharmaceutical, nutraceutical, and confectionery industries. Designed for early-stage R&D and clinical trials, this machine excels in producing a wide range of tablets and oblong forms, including multi-layered dosages with up to three APIs. The FlexiTab XL offers precise control over layering and sequencing, thanks to its enhanced data acquisition (DAQ) software. Capable of rapid changeovers, it supports tight schedule demands in research and development environments. The machine’s compact design ensures seamless integration into existing labs, while its hygienic build meets cGMP standards, facilitating fast and easy cleaning. Fully manual or automated sequencing of tablet production accommodates varied operational needs, making it a highly adaptable tool for any tablet formulation requirement.

The post Technologia kompresji tabletek w produkcji farmaceutycznej appeared first on Vekamaf.com Poland.

Generates and Distributes Ultra-Pure Water and Steam

Syntegon’s Pure Media Systems, featuring the Pharmatec MWFI System, revolutionize the generation and distribution of ultra-pure water and steam for pharmaceutical and biopharmaceutical industries. Designed with modularity and skidded drop-in installation, these systems employ advanced processes such as ultrafiltration and reverse osmosis to ensure high purity levels, effectively supporting applications in liquid formulations, tablets, capsules, and sterile solutions like saline and paracetamol. The systems facilitate continuous operation, integrating seamlessly with existing production lines through PLC automation, while maintaining superior energy efficiency with significant reductions in operational costs. Constructed with durable stainless steel, these systems are compliant with GMP standards, offering reliable sanitary performance. Maintenance is streamlined through easy-access designs, and optional ozone sanitation enhances microbial protection. Custom engineering support allows adaptation to specific process requirements, ensuring optimal performance across diverse pharmaceutical and biotechnology applications.

The post System generowania czystej wody do produkcji farmaceutycznej appeared first on Vekamaf.com Poland.

Mixes and Granulates Pharmaceutical Powders

The high-shear mixer granulator from Syntegon, featuring the innovative Hüttlin Gentlewing impeller, is specifically designed for pharmaceutical and nutraceutical production lines. It excels in mixing and granulating powders into uniform granules, crucial for oral solid dosage forms like tablets and capsules. Its unique impeller design ensures superior mixing and reduced wall caking, enhancing yield and process reliability. You can achieve granulation of challenging products like high-potent APIs and effervescent tablets, with batch capacities ranging up to 1,800 liters. Automation is seamless with its PLC-controlled system, supporting remote operation and integration into existing lines.

Offering energy efficiency through optimized motor control, this equipment minimizes solvent use and pollution. Available in top or bottom drive configurations, it features a purged sealing system to prevent cross-contamination, and is constructed from corrosion-resistant materials suitable for GMP environments. Maintenance is straightforward with integrated CIP systems, ensuring rapid cleaning cycles. Customization options like variable impeller designs and containment upgrades are available to meet specific production needs.

The post Granulator z mieszadłem wysokoobrotowym do produkcji farmaceutycznej appeared first on Vekamaf.com Poland.

Processes and Coats Pharmaceutical Powders and Pellets

The Syntegon Fluid Bed Processor offers pharmaceutical and nutraceutical manufacturers an indispensable solution for drying, granulating, and coating operations. Utilizing the unique Hüttlin Diskjet air distribution system and bottom spray technology, it provides homogeneous mixing and faster drying, catering to tasks like producing paracetamol tablets and vitamin D capsules. With batch capacities ranging from bench-top R&D sizes up to 1,600 kg, it ensures high throughput and versatility across processes. The processor’s three-component nozzle system enhances spray rates and product yield, supporting integration into continuous production lines with ease. Automated features, such as dynamic filtering and cleaning-in-place (CIP) options, meet stringent GMP standards, aligning with energy-efficient practices that lower operational costs. Available in industrial-grade materials to ensure chemical compatibility, this equipment exemplifies precision, compliance, and adaptability.

The post Procesor fluidalny do granulacji farmaceutycznej i powlekania appeared first on Vekamaf.com Poland.

Enables Precise Dosing and Continuous Production

The Xelum Continuous Manufacturing Platform from Syntegon is a transformative solution for the pharmaceutical and nutraceutical industries, offering seamless integration of precise dosing and continuous production for oral solid dosage forms. By leveraging discrete mass dosing, the Xelum platform eliminates the need for traditional scale-up, ensuring high content uniformity even for APIs below 1%. This system is ideal for producing a variety of products such as antibiotic tablets and antiviral capsules, thanks to its robust fluid bed processors that handle granulation and drying in a single chamber, avoiding wet granulate transfer and enhancing reliability. With throughput capacities ranging from 10 to 100 kg/h, Xelum supports rapid production cycles and maintains exact standards in API concentration.

The platform is fully automated, featuring PLC-controlled operations with direct process parameter transfers from R&D to production, allowing for efficient pilot and clinical trials without the constraints of scaling up. It accommodates complex formulations with contained capabilities for OEB4 materials and integrated WIP systems. Xelum’s design prioritizes energy efficiency, reducing production costs while maintaining flexibility for both tablets and capsules. Engineered to meet stringent GMP and FDA standards, it offers a clean-in-place (CIP) system ensuring fast, contamination-free cleaning, perfect for high-potent API development. Customization support allows for tailored configurations to suit specific manufacturing requirements, making Xelum a cornerstone for forward-looking production strategies.

The post Ciągłe wytwarzanie produktów farmaceutycznych appeared first on Vekamaf.com Poland.

Fills and Seals Capsules with Precision

The GKF 702 from Syntegon offers a versatile solution tailored for R&D labs and small batch production, capable of handling up to 42,000 capsules per hour. This capsule filling machine excels in precise dosing of both HPMC and gelatin capsules with a modular design that facilitates quick changeovers between different product types, including powders, granules, and liquids. Utilizing a slide-gate technology, it ensures minimal product loss and maximized yields. Integrated with automated systems for dosing and weighing, it optimizes productivity in pharmaceutical, nutraceutical, and health product manufacturing. The machine’s design supports seamless integration into production lines with minimal operational downtime. With robust material options and compliance with industry standards, the GKF 702 ensures reliability and efficiency in diverse processing environments.

The post Napełnianie kapsułek dla farmaceutyków i nutraceutyków appeared first on Vekamaf.com Poland.