Compresses and Shapes Tablets for R&D

The FlexiTab XL from Syntegon is a versatile single punch tablet press that caters to the unique production challenges in pharmaceutical, nutraceutical, and confectionery industries. Designed for early-stage R&D and clinical trials, this machine excels in producing a wide range of tablets and oblong forms, including multi-layered dosages with up to three APIs. The FlexiTab XL offers precise control over layering and sequencing, thanks to its enhanced data acquisition (DAQ) software. Capable of rapid changeovers, it supports tight schedule demands in research and development environments. The machine’s compact design ensures seamless integration into existing labs, while its hygienic build meets cGMP standards, facilitating fast and easy cleaning. Fully manual or automated sequencing of tablet production accommodates varied operational needs, making it a highly adaptable tool for any tablet formulation requirement.

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Enables Precise Dosing and Continuous Production

The Xelum Continuous Manufacturing Platform from Syntegon is a transformative solution for the pharmaceutical and nutraceutical industries, offering seamless integration of precise dosing and continuous production for oral solid dosage forms. By leveraging discrete mass dosing, the Xelum platform eliminates the need for traditional scale-up, ensuring high content uniformity even for APIs below 1%. This system is ideal for producing a variety of products such as antibiotic tablets and antiviral capsules, thanks to its robust fluid bed processors that handle granulation and drying in a single chamber, avoiding wet granulate transfer and enhancing reliability. With throughput capacities ranging from 10 to 100 kg/h, Xelum supports rapid production cycles and maintains exact standards in API concentration.

The platform is fully automated, featuring PLC-controlled operations with direct process parameter transfers from R&D to production, allowing for efficient pilot and clinical trials without the constraints of scaling up. It accommodates complex formulations with contained capabilities for OEB4 materials and integrated WIP systems. Xelum’s design prioritizes energy efficiency, reducing production costs while maintaining flexibility for both tablets and capsules. Engineered to meet stringent GMP and FDA standards, it offers a clean-in-place (CIP) system ensuring fast, contamination-free cleaning, perfect for high-potent API development. Customization support allows for tailored configurations to suit specific manufacturing requirements, making Xelum a cornerstone for forward-looking production strategies.

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A Robust, High Speed Double-Sided Tablet Press

The KIKUSUI Aquarius G-K tablet press is purpose-built for  pharmaceutical and health supplement industries. The robust design features interchangeable turrets, and the press can operate in dual mode thanks to the hybrid module and kit provided as standard.

The Aquarius G-K standard model offers an optional turret exchange lifter, and cart. The user-friendly touch screen on a swivel arm is standard, as are the punch head guard, upper and lower dust seals and bellows that minimize product contamination. These features combine to deliver a fast, reliable double-sided tablet press.

This robust machine features an 11Kw electric motor,10-ton pre and main compression rollers, and closed feeder and vacuum collecting system to fulfil high speed production and bi-layer tableting.

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Compact Laboratory Tablet Press

The KIKUSUI Vela G laboratory tablet press is a scaled-down version of the company’s large production machines, yet it achieves the same levels of functional excellence. It is suitable for compact laboratory conditions, and produces high quality tablet samples from very small amounts of powder granules.

This compact, flexible and easy-to-use equipment features standard compression turret interchangeability, allowing variable tooling on a smaller footprint. Powder and tablet contact points are in grade 316L stainless steel, with electro-polishing finish.

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High Speed Tablet Press with Quick Turret Exchange

The KIKUSUI Aquarius G-J standard high speed tablet press is a rugged, reliable machine with a compact design. It has automatic weight control ensuring the correct match with the compression force wave. Tablet rejection is by air pressure, which ensures single tablet rejection A swinging arm facilitates turret exchanges within twenty minutes.

An enclosed feeder and vacuum suction enable fast production with minimal powder loss. The upper punch head has a head guard to prevent loose powder sticking to machine tools. Dust seals and bellows keep the upper and lower punch areas clear of any powder that does escape.

A 7.5 Kw electric motor powers the KIKUSUI Aquarius G-J standard high speed tablet press, which has 10 ton pre- and main compression rollers. The external finish is stainless steel, while product contact points are stainless steel 316L with electro-polishing.

The machine with a throughout capacity delivers between 36,000 to 324,000 tablets per hour depending on tablet properties

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High Speed / High Containment Press

The KIKUSUI Aquarius C-H high speed / high containment tablet press features operator access through an optional glove box. These access points enable tablet testing during machine set-up, dust cleaning, and inspecting punches and dies.

Manual control is through a foot pedal, while the design enables relaxed operator posture throughout. However, the machine is fully automated in operating mode with auto weight regulation. There are maximum 25-kilonewton pre- and 50-kilonewton main-compression rollers.

This 18 station press has capacity of producing 10,800 to 75,600 tablets per hour.

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High volume, double-layer capable tablet press that increases productivity by 30%

The Sejong Pharmatech P320D and P580D series of double-layer capable tablet presses have been designed to offer immediate productivity improvements to tablet production lines. Designed to provide up to 10,000kgf of pressure and outputs of over 720,000 units per hour of single tablets and over 160,000 units per hour of double-layer tablet, these units offer some of the highest levels of performance.

The P320D and P580D series features an efficient single impeller feed system, reducing the number of parts required, simplifying and speeding up cleaning and maintenance. A new design of powder feed pipe improves powder flow, allowing for greater efficiency and higher output compared to other press designs.

The user interface is based on a clear 15” touch screen display, with clear and simple layout and controls. Advanced features include a completely graphical error display system in case of malfunction or performance issue, directing operator to the fault for rapid resolution. The operating system is fully 21CFR part 11 compatible, meaning record keeping for regulatory compliance and optimum performance is simple.

The P320D and P580D features a fully automatic discharge chute with sample gate. Rejected tablets are also automatically sorted when the machine sensors detect a defective tablet or as a result of the automatic weight control system. For double-layer tablet production, 1st layer sampling is available to ensure quality across both layers.

All punches and rails are protected by advanced load cells that constantly monitor the machine performance and prevent these vital parts from damage, prolonging machine life and reducing maintenance. Upper and lower punches benefit from an automated lubrication system, removing the need for operator input.

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Plug-and-play tablet press designed for lab and R&D environments

The Sejong Pharmatech P130S has been designed from the ground up as a lab-scale tablet press, and offers features that make it extremely flexible in pharmaceutical R&D.

Available in 3 models offering 9,600, 19,200 and 24,300 units per hour, the P130S is capable of producing both round or oblong tablets up to 25mm across and up to 8.5mm in depth, allowing for a wide variety of sizes.

The unit has a mechanical bar and round type feeder and offers full automatic weight control (AWC) for the rejection of any faulty tablets, removing the need for manual intervention for quality control.

Featuring a full touch screen interface, the P130S makes it easy for operators to control all aspects of the machine’s function via a graphical HMI. The control system features full 21CFR part 11 reporting compatibility, offering simple regulatory compliance.

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